Streck Cell-Free DNA BCT® Blood Collection Tube - Streck - 230469

Streck Cell-Free DNA BCT® Blood Collection Tube

Vendor: Streck

SKU: 230469
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Cell-Free DNA BCT stabilizes cell-free DNA for up to 7 days. It contains a preservative reagent that reduces the release of contaminating cellular genomic DNA that can occur during sample handling, shipping and processing. The cfDNA and CTCs isolated from stored plasma can be used in next generation sequencing assays that have been cleared or approved for use with samples collected into Cell-Free DNA BCT.

Performance characteristics of this device have only been established on the Guardant360 ® CDx assay and Guardant Shield™ assay.

Q: What is Cell-Free DNA BCT and what is it used for? A: Cell-Free DNA BCT is a direct-draw venous whole blood collection device intended for the collection, stabilization and transport of venous whole blood samples for use in conjunction with cell-free DNA next generation sequencing assays that have been cleared or approved for use with samples collected into the Cell-Free DNA BCT device.

Q: What NGS assays is Cell-Free DNA BCT FDA cleared for? A: Performance characteristics of Cell-Free DNA BCT have been established on the Guardant360 CDx assay and Guardant Shield assay. Laboratories should verify that their specific NGS assay has been cleared or approved for use with samples collected in Cell-Free DNA BCT before implementing this collection device. If their assay has not been cleared or approved for use with samples collected in Cell-Free DNA BCT, they should use of the CE/RUO version of the product.

Q: How long does Cell-Free DNA BCT stabilize samples? A: Cell-Free DNA BCT stabilizes cell-free DNA for up to 7 days. This extended stability eliminates the need for immediate plasma isolation and allows for room temperature storage and shipping, reducing pre-analytical variation that can occur during sample handling and transport.

Q: Does Cell-Free DNA BCT require cold chain shipping? A: No, Cell-Free DNA BCT allows for cold chain-free transport at room temperature. This simplifies logistics, reduces shipping costs and makes it easier to collect samples at remote or off-site locations without requiring specialized shipping arrangements or immediate processing.

Q: Why is room temperature blood sample stabilization important for cell-free DNA testing? A: Room temperature stabilization eliminates the need for immediate plasma separation and cold chain shipping, which are major logistical challenges for cell-free DNA testing. Without stabilization, blood cells can lyse during transport, releasing contaminating genomic DNA that dilutes the cell-free DNA signal and compromises test accuracy. Cell-Free DNA BCT solves this by maintaining sample integrity for up to 7 days at room temperature, enabling reliable testing even when samples must be shipped from remote locations.

Q: What is pre-analytical variation and how does Cell-Free DNA BCT reduce it? A: Pre-analytical variation refers to changes that occur in blood samples during collection, handling, transport and storage before laboratory testing. For cell-free DNA analysis, the most critical pre-analytical variable is cell lysis, which releases genomic DNA from white blood cells and dilutes the cell-free DNA targets. Cell-Free DNA BCT prevents cell lysis and stabilizes samples, ensuring that test results reflect the patient’s true biological state rather than artifacts introduced during sample processing.

Q: What extraction kits are compatible with Cell-Free DNA BCT? A: Streck Cell-Free DNA BCT is designed to be compatible with a wide range of commercially available extraction methods. For cfDNA extraction, Streck has tested the following: QIAGEN QIAamp® Circulating Nucleic Acid Kit; Promega Maxwell® RSC ccfDNA LV Plasma Kit; Zymo Research MAGicBead™ cfDNA Kit; Thermo Fisher MagMAX™ Cell-Free DNA Isolation Kit; Macherey-Nagel NucleoSpin® Plasma XS Kit

Key Features

  • 14-day cell-free DNA/genomic DNA sample stability at 6 °C to 37 °C*
  • 7-day CTC sample stability at 15 °C to 30 °C*
  • Available in 10 mL draw for research and ex-US registered applications
  • Benefit: Eliminates the need for immediate plasma preparation and CTC processing
  • Benefit: High-quality cell-free DNA can be used for a wide range of downstream research applications
  • Benefit: Allows for room temperature storage and shipping of critical samples

Applications

  • Liquid biopsy / cell-free DNA (cfDNA) blood collection, stabilization and transport
  • Circulating tumor cell (CTC) preservation
  • Research studies, drug discovery and assay development

Specifications

Intended use / regulatory status For In Vitro Diagnostic Use
Tube draw volume 10.0 mL
Tube size 16 mm x 100 mm
Cell-free DNA stability 7 days
Additive preservative reagent that reduces the release of contaminating cellular genomic DNA that can occur during sample handling, shipping and processing
Validated assays Guardant360 ® CDx assay and Guardant Shield™ assay
Stabilization claim (FAQ) Cell-Free DNA BCT stabilizes cell-free DNA for up to 7 days.
Cold chain / shipping No, Cell-Free DNA BCT allows for cold chain-free transport at room temperature.
Compatible cfDNA extraction kits (tested by Streck) QIAGEN QIAamp® Circulating Nucleic Acid Kit; Promega Maxwell® RSC ccfDNA LV Plasma Kit; Zymo Research MAGicBead™ cfDNA Kit; Thermo Fisher MagMAX™ Cell-Free DNA Isolation Kit; Macherey-Nagel NucleoSpin® Plasma XS Kit

Documents

Related Products

Specifications
  • Applications Liquid biopsy / cell-free DNA (cfDNA) blood collection, stabilization and transport; Circulating tumor cell (CTC) preservation; Research studies, drug discovery and assay development
  • Compatible with QIAGEN QIAamp® Circulating Nucleic Acid Kit; Promega Maxwell® RSC ccfDNA LV Plasma Kit; Zymo Research MAGicBead™ cfDNA Kit; Thermo Fisher MagMAX™ Cell-Free DNA Isolation Kit; Macherey-Nagel NucleoSpin® Plasma XS Kit
  • Instrument family BCT
  • Key use Liquid biopsy / cfDNA and CTC sample stabilization up to 7–14 days
  • Sub category Cell-Free DNA BCT
  • Technology Preservative blood collection tube stabilizing nucleated cells and cfDNA
links and documants
Streck Cell-Free DNA BCT® Blood Collection Tube - Streck - 230469

Streck Cell-Free DNA BCT® Blood Collection Tube

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