Solubility: Soluble in DMSO (10 mg/ml) or ethanol (1 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
STAT3 inhibitor
Functions
STAT3 inhibitor. Inhibits binding of tyrosine-phosphorylated peptides to STAT3 SH2 domain and inhibiting STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines. Alkyates four cysteine residues on STAT3. Exhibits potent antitumor activity. Protects against angiotensin II-induced vascular dysfunction and hypertension. An extremely useful tool to probe involvement of STAT3 in cellular signaling.
Application Procedures
First dissolved in DMSO (10 mg/ml) or ethanol (1 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
