Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
Storage: RT
Stability: ≥ 1 year.
Applications
Adenylate cyclase 1 inhibitor; Analgesic activity
Functions
A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC1. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation. Displays analgesic properties in a mouse model of inflammatory pain.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
