SRPIN340, SRPK inhibitor

Product Details

Formal Name: N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide

Molecular Formula: C₁₈H₁₈F₃N₃O

Formula Weight: 349.35

CAS Number: 218156-96-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

SRPK inhibitor

Functions

Selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Inhibits viral replication by inhibition of host SR protein kinases. Modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy and controls VEGF-mediated tumor angiogenesis in xenografts.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)