SR3335, RORα partial inverse agonist

Product Details

Formal Name: N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]thiophene-2-sulfonamide

Alternate Names: ML176

Molecular Formula: C₁₃H₉F₆NO₃S₂

Formula Weight: 405.30

CAS Number: 293753-05-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

RORα partial inverse agonist

Functions

Selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR. It was able to suppress gluconeogenesis in diet-induced obese mice.  SR3335 was able to upregulate uncoupling protein 1 (UCP1), a unique mitochondrial protein devoted to thermogenesis, in wild type mice leading to decreased body weight and fat mass. It inhibited the development of mouse and human TH17 cells in vitro and in vivo leaving thymic T cells intact.  SR3335’s ability to block pathogenic, but not protective TH17 cell function makes it an important new tool in the study of TH17-mediated inflammatory and autoimmune diseases.

Application Procedures

First dissolved in DMSO (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)