SR-1001, RORag agonist

Product Details

Formal Name: N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide

Molecular Formula: C₁₅H₁₃F₆N₆O₄S₂

Formula Weight: 477.39

CAS Number: 1335106-03-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

RORag agonist

Functions

A high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity. It inhibits the development of murine TH17 cells and suppresses the expression of cytokines. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model. Protects against pathologic neovascularization in various mouse models of retinopathy.  Active in vivo

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)