Splitomicin, SIRT1 inhibitor

Product Details

Formal Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Alternate Names: Splitomycin

Molecular Formula: C₁₃H₁₀O₂

Formula Weight: 198.22

CAS Number: 5690-03-9

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

• SIRT1 inhibitor

Functions

Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)