Sodium valproate, HDAC inhibitor

Product Details

Formal Name: 2-Propylpentanoic acid Na

Alternate Names: Valproic acid; Valproate Na; VPA

Molecular Formula: C₈H₁₅O₂ Na

Formula Weight: 166.20

CAS Number: 1069-66-5

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

 

Applications

HDAC inhibitor

 

Functions

Histone deacetylase inhibitor (IC50 = 400µM). Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.  Inhibits Aβ production, reduced neuritic plaque formation, and improved memory deficits in Alzheimer’s mouse models.  Improves stem cell reprogramming efficiency and enables efficient induction of pluripotency without introduction of the oncogene c-Myc. Clinically useful anticonvulsant

 

Application Procedures

First dissolved in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored under  at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)