SirtAct (CAY-10591), SIRT1 activator

Product Details

Formal Name: 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide

Alternate Names: CAY10591

Molecular Formula: C₂₀H₂₅N₅O₂

Formula Weight: 367.46

CAS Number: 839699-72-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

SIRT1 activator

Functions

Sirt1 activator (233% at 10 μM) Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. Inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. Prevents and cures experimental colitis in a mouse model.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)