Siramesine, Selective sigma-2 agonist

Product Details

Formal Name: 1’-[4-[1-(4-Fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4’-piperidine;

Alternate Names: Lu 28-179

Molecular Formula: C₃₀H₃₁FN₂O

Formula Weight: 454.59

CAS Number: 147817-50-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Selective sigma-2 agonist

Functions

Siramesine (Lu 28-179) is a σ2 selective agonist (IC50’s:  σ1 = 17nM, σ2 = 0.2nM). It produced non-sedating potent and long-last anxiolytic effects in rodents. Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage. Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)