Solubility: Soluble in DMSO (up to at least 50 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
Separase inhibitor
Functions
Inhibitor of separase (a cysteine protease that triggers chromosome segregation during mitosis and is highly overexpressed in many cancers), but not the related protease caspase-1, in vitro. HeLa cells with dysregulated separase activity showed severe chromosome segregation defects on treatment with 30 µM SIC5-6 indicating a potential attractive new chemotherapeutic target.
Application Procedures
First dissolved in DMSO (up to at least 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
