Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml).
Storage: RT
Stability: ≥ 2 years.
Applications
ALK4,5 and 7 inhibitor
Functions
Potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM). Inhibits TGFβ-induced proliferation of human osteosarcoma cells. Ehances growth and integrity of embryonic stem cell-derived endothelial cells. A frequently used agent employed in numerous stem cell differentiation protocols. Cell permeable.
Application Procedures
First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
