Salirasib (FTS), Ras inhibitor

Product Details

Formal Name: trans-Farnesylthiosalicylic acid

Molecular Formula: C₂₂H₃₀O₂S

Formula Weight: 358.54

CAS Number: 162520-00-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Ras inhibitor

Functions

Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains.  It has been investigated in the treatment of various cancers.  HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis. Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 µM).

Application Procedures

First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)