Solubility: Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
BET bromodomain inhibitor
Functions
RVX-208 is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD1. Increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo. Reduces atherosclerosis.
Application Procedures
First dissolved in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
