Solubility: Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
p34/cdc2 inhibitor
Functions
Potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine. p34 cdc2 IC50 = 0.2 µM. Also inhibits p33cdk2 and p33cdk5. Anti-angiogenic. Prevents PPARγ S273 phosphorylation, promoting browning of white adipose tissue. Enhances peripheral nerve regrowth.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.
