Description
CD40 Ligand, also known as CD40L, is a member of the tumor necrosis factor (TNF) superfamily. It is primarily expressed on activated CD4+ T cells, but can also be found on a small proportion of CD8+ T cells, platelets, B cells, basophils, eosinophils, NK cells, macrophages, dendritic cells, and smooth muscle cells. CD40L is implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and systemic lupus erythematosus. Elevated levels of CD40L are associated with cardiovascular events and autoimmune diseases.
Product Details
Alternative names: CD40 ligand, CD40-L, CD40L, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, TNFSF5, CD154, hyper-IgM syndrome, HIGM1, T-B cell-activating molecule, T-BAM.
Molecular Weight: 18.3 kDa
Formulation: Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 40% glycerol, 0.2M NaCl.
Concentration: 0.5mg/mL
Purity: > 95% by SDS-PAGE
Application: SDS-PAGE
Storage Condition: Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.
Research use only.
Documents
References
1. Somani, S., Menta, L., Wang-Johanning, F., Johanning, G., Hong, S., & Njoo, E. (2025, April 03). Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A. bioRxiv. https://doi.org/10.1101/2025.03.31.646140
2. Somani, S., Menta, L., Wang-Johanning, F., Johanning, G., Hong, S., & Njoo, E. (2025, October 27). Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A. Discover Pharmaceutical Sciences. 1, 25 (2025). https://doi.org/10.1007/s44395-025-00025-1
3. Gutti, M., Tsui, M., Yang, S., Xi, S., Luo, J., Desarkar, A., Xie, Y., Feng, M., Avadhani, U., Raghavan, S., Brierley-Green, E., Yu, E., & Njoo, E. (2025). Synthetic Derivatives of Vinpocetine as Antiproliferative Agents. Drugs and Drug Candidates, 4(4), 53. https://doi.org/10.3390/ddc4040053
Research use only.
