ReadyToProcess™ chromatography columns are validated high-performance bioprocessing columns that are supplied prepacked and ready for use. These single-use chromatography columns are prepacked with Capto™ Core 400 resin for purification of large entities such as viruses and viral vectors. Capto™ Core 400 resin is based on core-bead technology, enabling combination of size exclusion chromatography and binding chromatography for effective and productive separation.
Novel core bead technology and multimodal, octylamine ligand give Capto Core 400 dual functionality with both size exclusion and binding properties.
Efficient capture of contaminants while target molecules are collected in the flowthrough.
Significantly improved productivity and higher flow rates compared with standard size exclusion chromatography (gel filtration) methods.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Capto Core 400 is composed of a ligand-activated core and an inactive shell. The inactive shell excludes large molecules (cut off ~ Mr 400 000) from entering the core through the pores of the shell. These larger molecules are collected in the column flowthrough, while smaller impurities bind to the internalized ligands. Capto Core 400 is an excellent alternative to the size exclusion chromatography resins typically employed in the final stages of virus purification in vaccine manufacture.
