R-59022, DAG kinase inhibitor

Product Details

Formal Name: 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Alternate Names: Diacylglycerol kinase inhibitor i

Molecular Formula: C₂₇H₂₆FN₃OS

Formula Weight: 459.6

CAS Number: 93076-89-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

DAG kinase inhibitor

Functions

R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 µM in intact platelets). Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism. Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. Blocks filovirus internalization in host cells.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)