These ReadyToProcess chromatography columns are prepacked with Q Sepharose XL chromatography resin and are for biomolecule capture from clarified feed stocks. ReadyToProcess columns are validated high-performance bioprocessing columns that are supplied prepacked and ready for use.
High loading capacities give more productive capture from clarified feed stocks.
Strong anion exchanger designed for capture steps.
High chemical stability for effective cleaning-in-place (CIP)/sanitization protocols.
The hydrophilic nature of the base matrix ensures low levels of non-specific binding, leading to low levels of host cell-derived impurities in the elution pool.
About Q Sepharose XL
Q Sepharose XL is based on a highly cross-linked 6% agarose bead similar to the well-established Q Sepharose Fast Flow media.
Dextran chains are covalently coupled to the agarose matrix and modified with quaternary ammonium (Q) strong anion exchange groups through chemically stable ether bonds. The stable agarose matrix and long, flexible chains of dextran with bound charged groups work together to increase loading capacity, while allowing high flow rates.
Designed for downstream capture
With its high loading capacities and excellent physical and chemical stability, Q Sepharose XL is suitable for the capture step of a downstream process, which is characterized by large loads of crude samples.
