Pyocyanine, ROS generator

Product Details

Formal Name: 5-Methyl-1(5H)-phenazinone

Alternate Names: Pyocyanin; Sanasin; Sanazin

Molecular Formula: C₁₃H₁₀N₂O

Formula Weight: 210.23

CAS Number: 85-66-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

ROS generator

Functions

Pyocyanine, a redox-active phenazine produced by P. aeruginosa and other pathogens, is an electron receptor, which stimulates redox cycling in bacteria as well as in a variety of human cell lines. It enhances oxidative metabolism, which increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanine accelerates neutrophil apoptosis in vitro. Pyocyanine production by P. aeruginosa suppresses the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and associated reduction of local inflammation.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 week.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)