Prochlorperazine maleate, Dopamine D2 Antagonist; Endocytosis inhibitor

Product Details

Formal Name: 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate

Molecular Formula: C₂₀H₂₄ClN₃S • 2C₄H₄O₄

Formula Weight: 606.10

CAS Number: 84-02-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 15 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Dopamine D2 Antagonist; Endocytosis inhibitor

Functions

Inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME. Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs. A clinically useful antipsychotic agent with antimigraine and antiemetic activity.

Application Procedures

First dissolved in DMSO (up to 15 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)