These prepacked minicolumns are filled with MabSelect PrismA chromatography resin. This protein A resin has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein ligand. These features allow future demands in monoclonal antibody purification to be met, including processing of many bispecific antibodies.
Support high-throughput chromatography process development (HTPD) and scale-up, by allowing parallel screening of chromatographic conditions using a protein A minicolumn format and robotic workstation.
Facilitate chromatography resin screening of a wide range of parameters with small sample consumption.
Prepacked with protein A MabSelect PrismA chromatography resin.
Automation and parallel screening reduce experimental time and minimize hands-on time.
High-throughput workflow allows investigation of enlarged experimental workspace for better process understanding.
The enhanced alkaline stability of MabSelect PrismA also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest.
MabSelect PrismA builds on the proven track record of MabSelect and MabSelect SuRe resins in bioprocess-scale monoclonal antibody and Fc-fusion protein purification.
PreDictor RoboColumn units are prepacked, miniaturized columns that support HTPD using a robotic liquid handling workstation, such as Freedom Evo™ from Tecan, for fully automated and parallel chromatographic separations. Perform HTPD work using PreDictor RoboColumn units, alone or as a complement to PreDictor 96-well filter plates.
