PKSI-527, Plasma kallikrein inhibitor (selective)

Product Details

Formal Name: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide, hydrochloride

Molecular Formula: C₂₅H₃₁N₃O₄·HCl

Formula Weight: 474.00

CAS Number: 128837-71-8

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 5 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Plasma kallikrein inhibitor (selective)

Functions

Selective inhibitor of plasma kallikrein (PLK) (Ki = 0.81 µM) that attenuates arthritis and renal damage in rats with adjuvant-induced arthritis. Its combination with NO donor GSNO in blood samples led to strong platelet inhibition and thrombolysis. Blocked PLK-dependent TGF-β activation and significantly reduced hepatic apoptosis and mortality in a mouse model of acute liver injury.

Application Procedures

First dissolved in Water (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in water may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)