Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
PH Domain antagonist
Functions
PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87mgglioblastoma cells (IC50 = 37 μM). Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
