Pimaricin (Natamycin), Antifungal polyene macrolide

Product Details

Formal Name: Fermentation product from Streptomyces chattanoogensis

Alternate Names: Natamycin

Molecular Formula: C₃₃H₄₇NO₁₃

Formula Weight: 665.74

CAS Number: 7681-93-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 7 mg/ml).  Only slightly soluble in Ethanol (less than 1 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Antifungal polyene macrolide

Functions

Polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides such as amphotericin B) but by inhibition of amino acid and glucose transport. Blocks vacuole fusion at the priming phase via binding to ergosterol.

Application Procedures

First dissolved in DMSO (up to 7 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)