PI-103, PI3K, mTOR and DNA-PK inhibitor

Product Details

Formal Name: 3-[4-(4-morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl]-phenol

Molecular Formula: C₁₉H₁₆N₄O₃

Formula Weight: 348.40

CAS Number: 371935-74-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

PI3K, mTOR and DNA-PK inhibitor

Functions

A potent inhibitor of PI-3 kinase, mTOR and DNA-PK, IC50 = 8, 88, 150, 48,  20, 83 and 2 nM for p110α, p110β, p110ɣ, p110δ, mTORC1, mTORC2 and DNA-PK respectively. Synergizes with arsenic disulfide to eradicate AML stem cells by induction of differentiation. Inhibits the growth of gefitinib-resistant non-small cell lung cancer cell lines. Induces autophagy in drug-resistant glioma. Protects against a-synuclein-induced toxicity in human neurons by induction of macroautophagy.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)