Phosphoramidon, Neutral endopeptidase inhibitor

Product Details

Formal Name: N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan • 2Na

Molecular Formula: C₂₃H₃₂N₃O₁₀P·2Na

Formula Weight: 587.47

CAS Number: 119942-99-3

Purity: >95%

Formulation: powder

Solubility: Soluble in DMSO, methanol and water

Storage: -20°C

Stability: ≥ 2 years.

Applications

Neutral endopeptidase inhibitor

Functions

Inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM. Also inhibits neprilysin 2 (Ki~2 nM). Also inhibits endothelin-converting enzyme (IC50 = 0.68 μM). Induces a dramatic increase in amyloid-beta levels in rodents.

Application Procedures

First dissolved in DMSO, methanol and water, then diluted to aqueous buffer. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)