A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM). Inhibits growth and/or proliferation of a variety of cancer cells. Enhances self-renewal of embryonic stem cells. In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells. In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.
Application Procedures
First dissolved in DMSO (up to 12 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
