P7C3-A20, NAMPT activator; Proneurogenic agent

Product Details

Formal Name: 3,6-dibromo-β-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine

Molecular Formula: C₂₂H₁₉Br₂FN₂O

Formula Weight: 506.20

CAS Number: 1235481-90-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

NAMPT activator; Proneurogenic agent

Functions

A neuroprotective and proneurogenic agent acting via NAMPT stimulation. Displays neuroprotection and promotes endogenous reparative functions after traumatic brain injury (TBI). Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition one year after TBI in a mouse model. P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model. Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)