Solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Storage: RT
Stability: ≥ 1 year.
Applications
DUB USP7 inhibitor
Functions
Selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM). Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance. Displays antiangiogenic activity in vivo. Cell permeable
Application Procedures
First dissolved in DMSO (up to 20 mg/ml) or in Ethanol (up to 40 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.
