Vendor: ORGENTEC Diagnostika
SKU: ORG 871
In stock
Indirect immunofluorescence test for the qualitative determination of anti-nDNA IgG antibodies in serum or plasma.
Detection of antibodies against native double-stranded DNA (Anti-nDNA, Anti-dsDNA) is very important for laboratory diagnostics of systemic lupus erythematosous (SLE). Immunofluorescence assays based on antigens of the flagellate Crithidia luciliae have a high diagnostic specificity. Sensitivity is somewhat lower, especially in patients with no signs for an active disease state.
Antibodies against native DNA are more than specific markers for the disease; they are also suitable parameters for measuring lupus disease activity. Therefore, Anti-nDNA antibodies are among the most frequently detected autoantibodies that are associated with SLE. They are found in 95 % of SLE patients with renal involvement, in 50 – 70 % of SLE patients without renal involvement and in 40 % of patients with inactive SLE. Anti-nDNA antibodies are rarely found in healthy individuals.
Format: indirect immunofluorescence (IFA) slide kit.
| Parameter | Value |
|---|---|
| Tests | 120 (10 slides, 12 wells each) |
| Coating | Crithidia luciliae |
| Component | Contents |
|---|---|
| Slides Anti-nDNA Antibodies (nDNA) | Crithidia luciliae – 10 slides x 12 wells |
| nDNA Positive Control | anti-nDNA antibodies (for Crithidia luciliae) – 0.3 ml |
| IgG FITC/Evans | for human cells and Crithidia luciliae – 3 ml |
| Mounting Medium | mounting medium – 3 ml |
| PBS (10x) | phosphate buffer saline (PBS 10x) – 100 ml |
| Negative Control | Negative Control for IFA – 0.3 ml |
| Blotting Paper 1 x 12 | filter paper for 12 wells – 10 pcs. |
Instruction for Use Revision 3. Earlier versions and additional languages can be found in the document archive.
| Cat. no. | Product | Tests |
|---|---|---|
| ORG 871 | Anti-nDNA Antibodies (nDNA) | 120 (10 slides, 12 wells each) |
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