Anti-EBV (ZEBRA) IgM Alegria Monotest

Anti-EBV (ZEBRA) IgM is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgM antibodies against the ZEBRA protein of the Epstein-Barr virus (EBV) in human serum or plasma. It is used to detect an acute primary infection with EBV.

It is generally possible to differentiate between the latent and lytic stages of infection with EBV. In the latent phase, few copies of the viral DNA remain as episomes in the infected cells. These are replicated during cell division and are passed on to the daughter cells. In contrast, during the lytic stage, all viral genes necessary for the formation of complete virus particles are activated. One of the earliest resulting gene products is the ZEBRA protein (BamHI-Z-encoded Epstein-Barr virus replication activator), an immediate early protein (IEA) of EBV. This is a DNA-binding nuclear protein that activates other genes of the lytic phase; its expression precedes the synthesis of other molecules of the lytic phase.

The target antigens for this ELISA are IgM-specific peptides of the ZEBRA protein. The IgM antibodies it detects are found only during the acute primary phase and are early markers of an EBV infection.

Format: Alegria® Monotest strips for the fully automated Alegria® / Alegria® 2 analyzers.

Specifications

Documents

• Instruction for Use
• Safety Data Sheet

Instruction for Use Revision 6. Earlier versions and additional languages can be found in the document archive.

Ordering Information