Selectively inhibits the growth of cancer cells (IC50=0.4-4.3 μM) over normal cells (IC50=20.9 μM). Induces non-apoptotic cell death in glioblastoma cells and is active in an in vivo model. Covalently reacts with primary amines such as lysine side chains and phosphatidylethanolamine forming unique pyrrole adducts. Induces ER stress, paraptosis and autophagy.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
