Oltipraz, Nrf2 activator

Product Details

Formal Name: 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione

Molecular Formula: C₈H₆N₂S₃

Formula Weight: 226.34

CAS Number: 64224-21-1

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Nrf2 activator

Functions

Upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice. Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis. Attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. Promotes liver regeneration after partial hepatectomy.   Off target effects: Activates constitutive androstane receptor (CAR).

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)