Solubility: Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Cdc25 Phosphatase inhibitor
Functions
Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation. Inhibits the growth of a variety of human tumor cell lines. Acts via irreversible oxidation of the catalytic cysteine of CDC25.
Application Procedures
First dissolved in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
