Nitisinone, Tyrosine metabolism inhibitor

Product Details

Formal Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione

Alternate Names: NTBC

Molecular Formula: C₁₄H₁₀F₃NO₅

Formula Weight: 329.23

CAS Number: 104206-65-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Tyrosine metabolism inhibitor

Functions

Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM and 173 nM) and is in clinical use for the treatment of hereditary tyrosinemia type 1.  CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine – Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy. Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)