NDI-091143, Potent allosteric ATP-citrate lyase inhibitor

Product Details

Formal Name: Methyl 3-Chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate

Molecular Formula: C₂₀H₁₄ClF₂NO₅S

Formula Weight: 453.84

CAS Number: 2375840-87-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Potent allosteric ATP-citrate lyase inhibitor

Functions

Potent (IC50 = 2.1 nM ADP-Glo assay; 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase. NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C. It also synergistically potentiated the cytotoxicity of sorafenib.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)