Napabucasin, STAT3 inhibitor; Inhibitor of cancer cell stemness

Product Details

Formal Name: 2-Acetylnsphtho[2,3-b]furan-4,9-dione

Alternate Names: BBI608

Molecular Formula: C₁₄H₈O₄

Formula Weight: 240.21

CAS Number: 83280-65-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

STAT3 inhibitor; Inhibitor of cancer cell stemness

Functions

Inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.  Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models. Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer. Overcomes cisplatin resistance in non-small cell lung cancer.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)