Myriocin (ISP-1), Blocks sphingolipid biosynthesis

Product Details

Formal Name: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid

Alternate Names: ISP-1; Thermozymocidin

Molecular Formula: C₂₁H₃₉NO₆

Formula Weight: 401.54

CAS Number: 35891-70-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (25 mg/ml, warm) or methanol (2 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Blocks sphingolipid biosynthesis

Functions

Myriocin is a fungal metabolite with potent immunosuppressant activity. It inhibits serine palmitoyltransferase (K_i = 0.28 nM) blocking the synthesis of ceramide.  It was found to suppress melanoma cell proliferation by cell cycle arrest at the G ₂/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.

Application Procedures

First dissolved in DMSO (25 mg/ml, warm) or methanol (2 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or methanol may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)