Mycophenolate mofetil, Immunosuppressant prodrug

Product Details

Formal Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester

Molecular Formula: C₂₃H₃₁NO₇

Formula Weight: 433.51

CAS Number: 128794-94-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Immunosuppressant prodrug

Functions

A mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection. Is metabolized to mycophenolic acid in vivo  which acts by inhibiting the biosynthesis of guanine nucleotides via  inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages. IL-2-dependent T cell proliferation is also inhibited.  Inhibits microglial and astrocytic activation reducing cell death after neuronal injury. Active in vivo.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)