Solubility: Soluble in DMSO (up to 35 mg/ml), or in Ethanol (up to 35 mg/ml).
Storage: -20°C
Stability: ≥ 2 years.
Applications
Cardioprotective and neuroprotective agent
Functions
Muscone is a macrocyclic ketone found naturally in a glandular secretion of the musk deer which acts at human odorant receptor OR5AN1 and is used in perfumes. It suppresses inflammatory responses and neuronal damage in various models including a rat model of cervical spondylotic myelopathy and relieves inflammatory pain acting via the NOX4/JAK2-STAT3 and NLRP3 inflammasome pathway. In the cardiovascular system it alleviates myocardial ischemia-reperfusion injury and improves cardiac function in mice after myocardial infarction via enhancement of angiogenesis.
Application Procedures
First dissolved in DMSO (up to 35 mg/ml), or in Ethanol (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
