MRL-24, PPARg partial agonist

Product Details

Formal Name: (S)-2-(3-((1-(4-Methoxybenzoyl)-2-methyl-5-(trifluoromethoxy)-1H-indol-3-yl)methyl)phenoxy)propanoic acid

Molecular Formula: C₂₈H₂₄F₃NO₆

Formula Weight: 527.49

CAS Number: N/A

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

PPARg partial agonist

Functions

Displays high affinity for PPARγ with excellent anti-diabetic activity in mice but poor PPARγ agonist activity in transcription and adipogenesis assays. Highly effective (30 nM) at blocking Cdk5-mediated phosphorylation of  PPARγ. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)