Monastrol, Kinesin Eg5 and mitosis inhibitor

Product Details

Formal Name: 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester

Molecular Formula: C₁₄H₁₆N₂O₃S

Formula Weight: 292.35

CAS Number: 254753-54-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Kinesin Eg5 and mitosis inhibitor

Functions

Potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles. Does not affect other motor proteins or tubulin. Specifically inhibits the mitotic molecular motor kinesin Eg5, a motor protein required for spindle formation (IC50 = 14 μM). Mimics the effect of amyloid β on long term potentiation in a cellular model of learning and memory. Enhances regeneration of adult axons.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)