MLS-532223, Rho family GTPase inhibitor

Product Details

Formal Name: 1-(3-Nitrophenyl)-3-phenyl-2-propyn-1-one

Molecular Formula: C₁₅H₉NO₃

Formula Weight: 251.24

CAS Number: 16616-39-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Rho family GTPase inhibitor

Functions

MLS-532223 is a high-affinity selective inhibitor of Rho family GTPases (EC50=10 μM). It inhibits EGF-stimulated Rac1 activation (3-10 μM).  Cell permeable.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)