ML365, Potent and selective K2P3.1 blocker

Product Details

Formal Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

Molecular Formula: C₂₂H₂₀N₂O₃

Formula Weight: 360.4

CAS Number: 947914-18-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Potent and selective K2P3.1 blocker

Functions

ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K_2P3.1 (TASK-1). It also less potently (IC₅₀ = 4.07 µM) blocks the K_2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome. ML365 improved the efficacy of Levetiracetam in chronically epileptic rats. It suppressed the release of TNF-α, IL-6, and IL-1ß in an LPS-induced inflammatory model via regulation of NF-kB signaling.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)