ML-324, JMJD2 inhibitor

Product Details

Formal Name: N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide hydrochloride

Molecular Formula: C₂₁H₂₃N₃O₂ · HCl

Formula Weight: 385.90

CAS Number: 1222800-79-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

JMJD2 inhibitor

Functions

Inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)