Minocycline HCl, Neuroprotective; Antiapoptotic

Product Details

Formal Name: [4S-(4α,4aα,5aα,12aα)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide hydrochloride

Molecular Formula: C₂₃H₂₇N₃O₇ · HCl

Formula Weight: 493.95

CAS Number: 13614-98-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml), or in Water (up to 10 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Neuroprotective; Antiapoptotic

Functions

Displays antiapoptotic, anti-inflammatory activity. Prevents neuropathic pain in a rat sciatic nerve injury model. Reduces MMP-9 activity. Attenuates disease severity in mouse models of multiple sclerosis. Displays neuroprotective activity. May be effective in methotrexate-induced lung fibrosis. Orally active and brain penetrant.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), or in Water (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)