Milbemectin, RDL GABA agonist; Glutamate-gated Cl channel activator

Product Details

Formal Name: Milbemectin is a mixture of Milbemycin A3 (~30%) and Milbemycin A4 (~70%)

Milbemycin A3: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-milbemycin B

Milbemycin A4: (6R,25R)-5-O-demethyl-28-deoxy-6,28-epoxy-25-ethyl-milbemycin B

Molecular Formula: C₃₂H₄₆O₇ (A4)

Formula Weight: 542.7 (A4)

CAS Number: 1799297-76-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (20 mg/ml); or Ethanol (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

RDL GABA agonist; Glutamate-gated Cl channel activator

Functions

An allosteric agonist at the Drosophila RDL GABA receptor. Also acts as an agonist at glutamate-gated chloride channels in insects. Mutations (specifically a G326E substitution) in the glutamate-gated chloride channel 3 (GluCl3) in phytophagous mites abolishes agonist activity resulting in resistance. Commercially used as an acaricide.

Application Procedures

First dissolved in DMSO (20 mg/ml); or Ethanol (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)