Metolazone, UPR activator and longevity inducer

Product Details

Formal Name: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Alternate Names: SR 720-22

Molecular Formula: C₁₆H₁₆ClN₃O₃S

Formula Weight: 365.8

CAS Number: 17560-51-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (36 mg/ml)

Storage: -20°C

Stability: ≥ 2 years

Applications

UPR activator and longevity inducer

Functions

Activates mitochondrial unfolded protein response (UPR^MT) and increases C. elegans lifespan. Clinically useful diuretic that inhibits the thiazide-sensitive Na⁺-Cl^– cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption. Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency.

Application Procedures

First dissolved in DMSO (36 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)