Solubility: Soluble in DMSO (up to 10 mg/ml with warming)
Storage: -20°C
Stability: ≥ 1 year.
Applications
SIRT6 allosteric activator
Functions
Specific, allosteric activator of SIRT6 (EC50 = 10.3 µM) activity toward H3K9ac and H3K56ac. MDL-800 is ten times less potent against Sirtuins 2, 5, and 7, and is inactive against HDACs 1 through 111. At 20 µM, it induced DNA repair in iPSCs derived from aged mice, promoting genomic integrity and differentiation potential. Inhibits NSCLC cell proliferation (IC50 ~ 30 µM), and suppressed tumor growth in a HCC827 xenograft mouse model.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.
